Wednesday, July 10, 2013

Is Rondo a top 10 player in the NBA?

I just like to see him behalf of the ownership group thank you to bread and Tracy and their family for believing in us. Believing in the power of Celtic pride when you take charge of this. Organization. And all of the tradition and pride it was built by so many great people in the past. Your -- your obligation is to build. That the Celtic pride and take it forward. We think by having bread in this and we hear as a key part. Of the Celtics going for. We're doing everything we can to bring back. The championship ways we've been there before. And we wanna get that there. Out of courses so to go to Seligman managing general partner -- grows back talking about -- Brad Stevens and the rebuild process that is under way at. Breakneck speed 61777979237. I don't think we could find a more interesting. More at a -- -- overstate the word and over to the case news or inflammatory. But notable quote. That would pop Peter show rally dumping on Sagan prior to the draft -- said this kidneys to focus more and become more of a professional. But then -- To Steve bullpen in the Boston Herald a quick break talking about -- to Steve bullpen in the Boston Herald over the weekend said it's important quote. -- left us period. Doctor left us no -- and will take that away it was his idea and he left and we made the best of it. Not exactly the bill would -- that docs now has. Mean at the real believe prospect in this absolutely white in what David just woke up -- -- -- to the clippers of course wanted to leave the kind of forced his way out and now we go on -- -- Necessary for docking -- -- to -- at this because Doc Rivers has been perceived that we I think is a very nice guy yesterday as a first time really in his life. Took some serious heat some serious brush back for the with the media player no as a coach. Not really no not for the first time -- and everything was kind of focused on him he was a guy was taking some heat. You liked it yeah like I felt like the -- awhile -- and and so. Fifth spot and I think what he probably thought he was telling truth to some extent -- -- -- -- to justify the that he did problem we talked to any law -- that we can do it this way that makes him look good. But I still don't know why Doc -- just didn't -- depressed -- -- where I don't -- I want to coach the clippers are trying to win a championship I thought made a sign that wanted to -- want to. They have thought less of him and I think some people do now because he's -- and that was a mutual a mutual decision here. They wanted to go I wanted to go -- let's make the best of it which is not true at all. What anybody thought less of doc and he just said. I don't -- build or added this I think after nine years my voice is resonating anymore right I don't think it's resonating anymore. Yeah I think I've reported happened was people who have been happy days that they -- people so that's got to disappoint you wanna rebuild that's too bad that have been over but I just -- I totally understand it now it's been one. We do we exactly and it's -- -- likes when guys like -- aren't giving up on it but I mean listen -- and you said from the start -- quantum -- were quick process. Doc wanted to leave. How -- doctors can't say one leave. He thinks that makes them look bad when we looked worse. All right so where we go from here -- we have we have yet to convene or reconvene you and me and injure -- Rebecca after few more days of vacation. About his Brad Stevens situation first things first I will say this I don't know how we get. I don't know how we pulled -- off without his name even appearing on any buddies list and no I mean we have Kevin Eastman we have Lara mango we had. And Gandhi and Gundy to we had every right George Karl yeah. Nobody said Brad Steve never heard is they never heard my name -- not even close was he can keep -- Kennedy does a good job you know what you just fluent in Apple's got the deal. Probably was part of the deal. I mean if if you saw. Stephens walking through Logan Airport. And a car service picking up. How long cortex which doesn't -- just saw Brad Stevens unbelievable -- are the -- are -- boss -- course is in that spot -- angry yet I think they did it right you don't -- take care but no bad play and were missing guys. Its -- -- -- -- -- -- Indianapolis story. Believe it connects to the centerpiece a -- Indianapolis airport are. I have a very interesting theory about them all year and not not that but in terms of a of why this guy why now and what the plan is right out of it that's different than a lot lot of people think it's going to be. Now I did hear you on a couple publications say you know get -- Iran there's no reason have Rondo here if you're gonna -- Rondo might. We get ten games you don't wanna win or 101 -- and I don't wanna win yes. You still stand by that yes your goal unit Rondo is gonna be here here's what for Bret Stephens I want the press conference the other day I'm still much terrific about our -- Brad Stevens yes I don't know yet. I want him it would get its it was at least it's honest yes and straightforward he'd be replaceable. I play opening up. So what I want for Bret Stephens -- -- -- -- -- needed to trim your boss at that that's it I mean I think about -- and get it. On the spot that debate distorted to a half million dollars and say got a six year making it -- -- published Iowa said yes yes that's wanna do we want a panic panic panic. Brad thanks Steve so you believe that Danny was telling the truth when he splendid awkward situation but now you don't leave -- telling the truth when he says we. Are the Boston Celtics we are not tanking -- -- before. Running the Celtics apart for you believe that he will never -- -- he did did tech on purpose pick yourself forever trying to Oden or Durant of course. -- I spoke to tank it makes sense yet. In the NBA you have to -- I think here's my Ethier -- I think there was a eight the high level discussion. Where they look at do we need to get all the way down to the dregs of the earth. To get in -- lotteries that situation right and maybe get -- or some other superstar savior. And and and build our way back up or -- we go down a little bit. And turn this around a little more quickly. Now what do you think the marketing people. Would think the ownership people would think that people -- think the people -- helping the -- over there. Would like to have happened all -- liked smallest window possible before -- -- window possible without falling as far as -- shore now is it isn't possible to combat to championship driven. I'm not suggesting you know not one not two not three not four not that -- championship driven but competitive as it were the last couple of years with KG and Paul Pierce. Without having to sink to the very bottom and lose. You know 88 TV -- be the sixth or seventh best team in east for a year or two I guess you could do that are right let me ask -- this. If you do tank. And I don't think they are entitled again is that allowed to happen and I don't think -- expects that to happen is going to be bad next year as ugly it's not going to be what a lot of KG ball gears here OK but I don't think it's going to be as bad -- I think they want to be as bad as you want to beat to get Americans think about this. Every single game and they get the most ping pong ball 45% 25%. Chance of getting that guy right -- got -- -- give the guys -- four -- the guys. Do you suspect. Wheat instead of a site anybody else sharp whatever -- us. Will he EB. -- -- To guarantee you'll be a top five or ten player in the NBA. Let's say two or three or four years Williams. Radios any of those no idea no of course you'd -- we know of course -- them. Everybody thought it was going to get organ player of course in the short -- -- have played since you know 1934 yes okay. My -- you how one doubles guys -- Do you Rondo on top ten players -- year. Up what's best player on the team per Diem yeah yes where every -- -- yes shark riskiest job they did the blood the after the break and we'll get into the if you look at. Top ten player John. Just of the top ten players and yet not an expert. -- stay at the top of his game. He's a top. Three or four point guard helped any but few of the top ten players -- what -- you -- my point is that you might not get something he's part of your solution right he's part of what can make you better yeah and here's the key in my whole theory -- -- I think you're gonna see a different -- And I think you're gonna see it Rondo. Who buys into this I think the generally perceived. Why. Needs out OK I think the generally perceived need jerk reaction is I'll Rondo is gonna eat. Rick Moran asked for lunch yes he has not gonna put up with some guy who's 36 years of age who looks like he's 26 years of Beijing -- every third Wednesday right. To tell him what to do and that's the key. He's not gonna tell him what to do he's going to be the justice what doc was. The reason. -- and Rondo butted heads is because they butted heads should. Rondo is a headstrong defiant. Real -- you tell me but I'm telling you read don't tell me like I'm telling -- dark. And doc I think -- headstrong and Rondo was headstrong and that's why that relationship wore thin at the end -- pay Bret Stephens twenty million dollars to knock coach Ron. -- to coach Rondell went to work to coach with -- -- to work with Rondo he's already made a phone call. He's going to lower himself to get on the plane and go and just Rondo is but but isn't that what is necessary in this day and age. I mean. Managers have gone to Manny Ramirez's house and knocked on the door joke argued our time with -- -- decide what exactly assists this happens I understand that -- but here's here's the thing okay. You bring Rondo back next year Stevens -- you win 3637. Games you -- the twelfth pick you are no winner. How was that telling audit team -- and become a contender again you have other picks you have picks you can package you can you can make passage picks for white. You're a great player opt out -- guarantee -- have a great player not yet know what ray player as your best player Robbie -- when -- championship Rondo is a great. Player you already have a great player -- -- -- tell -- your best -- you -- -- an -- championship. With it with him and that everybody knows the theory in the NBA now is you need at least two maybe three superstars on the team. -- -- Yes yes out on the heat three superstars but it was or -- have three superstars. You were and or get work when I noticed a documentary yet once superstars log on to star. Which in and he won the last two of the best power in the world yes Oklahoma City has one of the best players in the world. -- all time great player. I don't know Wiggins can be that kind of player you read things that suggest he might Rondo is not a clinical them. But the point 5% change I think brought already does not see the -- from this -- you are you watching this -- has ever done on his own. -- had the upper to do it now is almost too sudden she gave his game to a certain extent to KG and Paul is there any possibility you may not be as of now those guys are on. I think -- be harder to win without those guys certainly I don't think he will be less of a problem -- you think you are now you think because Doc Rivers Paul Pierce and Kevin Garnett gone. We're -- even knew the -- The new leadership abroad. I think there's a possibility that yes yes I think I think you'll see I understand this. Rondo in spite of what he would want you to believe. Cares what people think about him I don't doubt that. The the guy who snarls and says dog crap you think -- -- is the guy that gives a crap about holding I concluded that god is defined as it I don't care what you say don't get it doesn't matter to me is the guy that matters to yet -- is that guy I don't doubt that OK I'm with you on all right. So at this point I think Rondo understands that -- the other thing about -- personality that he is is key to steal. -- Loves to prove people wrong. Rondo if you say Ron that you can't do this by god he's gonna do that it -- are still hundreds are said Rondo if a bunch of set right read no way in hell Rondo can get back by opening night -- Himself to get back -- opening night. Picture the best of both worlds John which is just bring Stevens and keep -- for the whole year. How different opponent and why. Now I don't just adjusting having the opening night but don't get Iran if you -- -- -- -- -- detestable want to bring -- back when I teach and educate the law out all year you don't trade to get I picked that high tech plus one. That's the best situation so just an entire tank here what what's the point of not take. Well be that as it may I don't think you'll be back for opening night and we'll be back sometimes and on November December may be after the first of the year -- of the case may be but my point is to the two true personality traits of Rondo. He wants to prove people wrong and everybody in the world the same Rondo is gonna be a problem. -- is gonna eat this guy for lunch Rondo is going to be a problem as the leader without KG and Paul Pierce in the locker room. -- -- Toronto looked at this is as you -- about. I think this other another thing at play here -- Rondo understands what his legacy what his reputation is becoming in this sleek. And maybe he's early in May be -- defiant but I think he wants to be liked and admired. And I to a certain extent Ronald looks this and says well I think along with -- in my ideals I didn't get along with -- I'm part of the problem. What do this again and cement the fact that I'm an eighth hole to be liked and admired widening trying to liked and admired the last five years. Why did you suddenly -- -- woke up you know like that you did spot alarm about the fact that it's not a bleeding and he -- yet be liked and admired today. What if -- six months ago because it wasn't his team. It was KG and Paul head of the team over to we heard the story last year that's true bit let me did you buy it now. Don't know who wants it. Strategies to Garnett and Garnett status and and impulse to a lesser extent a -- and he was just that he was sort of like the ringmaster of the three ring circus right I'm telling you ball goes here ball goes there. Now it's all different he's in charge so the -- largely the success and failure of this basketball team for the short term and the long term. Has fallen on -- those shoulders and his fault not Rondo is reputation and you pick healthy Rondo is one of the ten best basketball players -- it. You do you and you really -- at a practice that we respectfully disagree I don't their robot up the top thirty and here's the other key -- this guy is a teacher of the game. And not Iran not these tell Rondo left foot right what's yet Stephen yeah. He's not been opened in L group who coached his point guard every step away -- literally every step of the way up the floor -- stuck on notice. Do you think any spent any amount of time choosing a coach. From his personality not only is basketball acumen. But as personality and his approach what kind of guy he was going to be -- think that any club course of course and this is his hand picked guy. He deferred he's humble. He wants to work with people wants to be on the same page. He's not a coach away doc coached -- could do this Rondo do that right together pitino was pitino had no interest or rebuild wanting to -- and yet know which is I think Stephen's fine for two or three years to be. I was you see some in the I don't think this picture contract this again of course absolutely he's -- this young guy who's making you know how what -- with me. -- and point two million dogs and make 211. Read Mick and 22 for six. -- will be charged with coaching these young players these draft choices these assets that Danny is going to bring -- As well as he possibly can't get along with Rondo and let's see where we go and had decided Brad -- side will be -- noted terrific leader. Great team guy Ron Wolf he's not a great team guy -- -- well. I think there's a potential became evidently nothing -- so I think there's a chance that this is what it's gonna happen about it it'll happen. I I I still pretty -- -- at a -- will go to Kentucky right and look Rondo in the ally and that I need you help me. Win some basketball games I'll -- off the ice I need you to tell me what I can do to make you the best player you can possibly be I want you to tell me. What kind of system you wanna run. I want to tell me what works best a gathering information or Rondo you not to be my adversary. I want you to be. It nice conversation I think the NBA's two with nice conversations in July and go to sell Regina for their. Training camp or -- if you like you -- they go this year and 42 minutes in the first practice again argument that's OK right. Mark and never ever does communal forces always in the windows arguments we Brad inaudible was arguments to -- seepage is there to take it from on that. He's used -- massage used it took to rub shoulders up to make him feel loved it welcomed and valued at 22 million dollar offer yes. Teacher teacher picture. Offer organized always needed to -- position to be in the shirts 61777979237. Text line 37937. Steve A Smith. Join us in the 8 o'clock hour George Ani -- the rest your phone calls next with Dennis and Callahan.

Source: http://audio.weei.com/a/77726082/is-rondo-a-top-10-player-in-the-nba.htm

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Tuesday, July 9, 2013

Thousands flock to Texas Capitol over abortion

AUSTIN, Texas (AP) ? Texas Republicans pushed ahead Monday with aggressive efforts to pass tough new abortion restrictions they failed to approve last month, scheduling a House vote as thousands flocked to the Capitol for an anti-abortion rally and a marathon public hearing about the legislation.

Activists for and against the proposed restrictions descended on the Capitol for the hearing that started at 10 a.m., wearing their signature colors. About 2,000 anti-abortion demonstrators in blue staged a Capitol evening rally that heavily invoked God and Biblical teachings.

The Rev. Robert Jeffress, the controversial pastor of First Baptist Church in Dallas, energized the crowd by describing the debate over abortion as a fight "between the kingdom of God and the kingdom of Satan."

And about 100 yards away, about 1,000 orange-clad abortion-rights protesters gathered at the Capitol gate to march through downtown Austin.

Gov. Rick Perry, who was in San Antonio on Monday afternoon to announce that he will not seek re-election in 2014, has pledged the Legislature's Republican majority will pass the new restrictions in the current 30-day special session. The House Calendars Committee met early Monday to schedule a Tuesday debate and vote on the measure.

Monday night's rally had a smaller turnout and less energy than a July 1 abortion rights rally that drew about 5,000 people. But anti-abortion groups have the luxury of knowing their bill is on track to becoming law.

"We will pass this bill," Lt. Gov. David Dewhurst told the cheering crowd that held signs saying "Unborn Babies Feel Pain" and "Abortion Kills Children."

Rally organizers urged bill supporters to pack the House gallery for Tuesday's vote.

"To see this coming to life is historic. It's what we've been waiting for since the early 1970s," said Ann Storm, of Arlington, who drove about three hours to the Capitol with her mother to attend the rally and witness Tuesday's House vote.

Inside the Capitol, the Senate Health and Human Services Committee hearing was expected to last past midnight.

More than 2,000 people ? some of whom showed up before dawn ? registered to testify or log a position on the bill. About 475 signed up to give two minutes of testimony each.

At issue are identical House and Senate bills that would ban abortions after 20 weeks of pregnancy, require that the procedure be performed at ambulatory surgical centers, mandate that doctors who perform abortions obtain admitting privileges at a hospital within 30 miles and that even nonsurgical abortions take place in a surgical center.

Only five out of 42 clinics in Texas qualify as ambulatory surgical centers, and they are in major metropolitan areas. Many clinics would need to relocate to meet ventilation requirements and to have the space required for operating rooms and hallways.

Opponents of the bill say the new requirements are unnecessary and would force most Texas abortion clinics to close. Supporters of the bills say they want to reduce access to abortion and improve women's health care. Texas health officials report that 72,240 abortions performed in the state in 2011, including 374 that happened after 20 weeks.

The 20-week ban is based on the scientifically disputed claim that a fetus can feel pain by that point and thus, deserves protection from abortion.

Other states have passed similar restrictions, including some that are being challenged in court, but Texas has been at the center of the national abortion debate since a Democratic state senator succeeded in preventing the Legislature from passing the new restrictions last month by staging a nearly 13-hour filibuster on the session's last day.

Perry called lawmakers into a new 30-day special session to take up the bill again and activists on both sides have kept up a steady presence at the Capitol.

Last week, a House panel heard eight hours of testimony from about 100 witnesses but cut off thousands more who had registered. Unlike the House, which has online registration, the Senate required witnesses to register in person.

Senate committee chairwoman Sen. Jane Nelson, R-Flower Mound, allocated more time for testimony said she still needed to place a time limit. Nelson said the panel would not vote at the hearing's conclusion.

"We're going to run straight through the night," Nelson said.

Before any of them started, Sen. Bob Deuell, R-Greenville, called abortion an "American holocaust" and placed two pairs of infant sneakers at his desk as a reminder of fetuses that were aborted before they could be born.

During the hearing, activists from both sides roamed the Capitol, packed waiting rooms and waited for their chance to speak. Security was tight, but the gathering lacked the tension of the previous week when demonstrators chanted, sang and prayed their way around crowded hallways.

Even with only a short time allowed, several women told emotionally wrenching stories of regrets about having abortions or delivered passionate defenses of a right to choose whether to carry a pregnancy to term.

Vanessa Riley, who opposed the bill, said she had an abortion after learning in her second trimester that the child she was carrying had severe developmental problems.

"My husband and I made the most ethical decision we could," Riley said. "I was preventing pain, not causing it."

At the anti-abortion rally, Attorney General Greg Abbott ? who has used a wheelchair since he was 26, when a tree collapsed on him during a jog, leaving him paralyzed in both legs ? said he would "stand for life" with demonstrators in spirit.

"You don't have to stand to fight for life," said Abbott, who is expected to soon announce if he will run for governor in 2014.

Source: http://news.yahoo.com/thousands-flock-texas-capitol-over-abortion-030208528.html

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Thanks to clouds, some 60 billion planets are habitable in Milky Way

New research that factors in the influence of cloud cover on alien climate has extended the habitable zone around red dwarf stars to include twice as many planets.

By Elizabeth Barber,?Contributor / July 2, 2013

This photo taken in June 2013 shows the Milky Way galaxy over Gem Island, on the east coast of Malaysia.

Vincent Thian/AP

Enlarge

?Life would be dull if we had to look up at a cloudless monotony all day,? writes Gavin Pretor-Pinney in the Cloudspotter?s Guide.

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That, and life would be more difficult to find.

New research that factors in cloud cover and its influence on alien climate has extended the habitable zone around red dwarf stars to include double the number of planets in that life-supporting region. That means that some 60 billion habitable planets could be orbiting red dwarf stars in the Milky Way galaxy alone.

Scientists had previously believed that each red dwarf had just one Earth-sized planet in its habitable zone ? the sweet spot just far enough from the sun that the planet?s water doesn?t turn to vapor in the overwhelming heat, and just close enough that water doesn?t freeze without the reassuring warmth of the sun?s glow.

But now that habitable zone, once thought to be fairly small around the eponymously named red dwarfs ? the stars are small and faint, relative to our sun ? has been expanded. That?s because the formula for calculating the habitable zone of far-flung planets had not previously included how cloud cover might mitigate the star?s influence planets.?

"Clouds cause warming, and they cause cooling on Earth," said Dorian Abbot, an assistant professor in geophysical sciences at the University of Chicago. "They reflect sunlight to cool things off, and they absorb infrared radiation from the surface to make a greenhouse effect. That's part of what keeps the planet warm enough to sustain life."

Building 3D computer models that simulate how clouds behave on alien planets, researchers at the University of Chicago and Northwestern University found that where there is surface water there are also water clouds. On planets close to their sun, those clouds exert a significant cooling effect, which allows those planets to retain their water, despite their closeness to the dwarf star?s heat. That means that the habitable zone has been extended inward, closer to the star, than had been imagined to be possible.

The researchers plan to test their findings, published in Astrophysical Journal Letters, with the James Webb Telescope, which will go into orbit into 2018, taking the temperature of those alien planets during their days and nights to measure cloud cover.

But the big question is, when an alien looks up at that planet?s clouds, what strange shapes, what foreign animals or objects or ideas, does he or she see?

Source: http://rss.csmonitor.com/~r/feeds/science/~3/scFWb6mO8BM/Thanks-to-clouds-some-60-billion-planets-are-habitable-in-Milky-Way

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Texas Governor Perry expected to disclose political future

By Jim Forsyth

SAN ANTONIO, Texas (Reuters) - Texas Governor Rick Perry, the nation's longest-serving governor and a failed contender for the 2012 Republican presidential nomination, planned to announce Monday whether he will seek re-election next year.

Perry, 63, is best known nationally for his poor performance as a Republican candidate for the White House. During a debate in November 2011, he famously forgot the government departments he would abolish if he were elected to the White House and dropped out of the race a few weeks later.

Perry has set a 1 p.m. news conference Monday in San Antonio to make what was billed as an important announcement.

Asked on "Fox News Sunday" whether a presidential run is in the cards, Perry said: "Well, certainly, that's an option out there, but, again, we got a lot of work to do in this building right behind me over the course of the next couple of weeks that have my focus substantially more than even 2014 or 2016."

The timing of his announcement comes shortly after he rehired his former presidential campaign communications director Mark Miner, and as Perry is locked in a heated battle with Texas Democrats over restrictions on abortion.

"In Texas, the road to the governor's office goes straight through the Republican primary electorate," said Mark P. Jones, a political scientist at Rice University in Houston. "Right now, Perry retains very strong support among Republican primary voters."

Perry is motivated to overcome his embarrassing national stumble, Jones said. Perry and his consultants later blamed the debate gaffe on pain from a recent back surgery.

"Pundits and liberals and Perry opponents care far more about the 'oops moment' than do voters in the Republican primary," Jones said. "As long as he does well on the campaign trail."

Perry took office in December 2000 after then-Texas Governor George W. Bush was declared winner of the disputed presidential election over Democrat Al Gore. Perry was elected to a full term in 2002, and re-elected 2006 and 2010.

If he runs for a fourth four-year term, Perry may face what is known around Texas as "Perry fatigue." Perry is already by far the longest serving governor in Texas history, and a recent poll by the Democratic-leaning PPP polling group indicated that 60 percent of Texans don't want him to run for governor again.

A poll by Rasmussen Reports last week showed Perry running sixth among Texas Republicans for president in 2016. The leader among Texas Republicans is Ted Cruz, Texas' junior U.S. senator.

Perry brushed aside those concerns on "Fox News Sunday."

"You know, polls are polls. As a matter of fact, I think it was four years ago that showed us 25 points down to a sitting U.S. senator," Perry said.

Perry defeated Senator Kay Bailey Hutchison, who was considered the most popular politician in Texas, by 22 points to win the Republican primary in the 2010 governor's race.

Perry also is embroiled in a battle over abortion restrictions that made State Senator Wendy Davis a national figure and likely Democratic candidate for governor in 2014.

Democratic Party consultant Jason Stanford said the uproar over Davis may sway the governor, who opposes abortion.

"Before Wendy Davis became a national star, people weren't giving Rick Perry good odds of running for re-election," Stanford said. "Everybody assumed he would go off into the sunset and get ready to run for president... Now it looks like he's spoiling for a fight."

(Reporting by Karen Brooks in Austin and Jim Forsyth in San Antonio; Editing by Greg McCune, Barbara Goldberg, Doina Chiacu)

Source: http://news.yahoo.com/texas-governor-perry-expected-disclose-political-future-185449621.html

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Tuesday, March 19, 2013

iPhone Still Ranks Far Above Samsung Galaxy Line In Mobile Ads, Says Velti

Screen Shot 2013-03-18 at 4.23.55 PMA lot of headlines have focused on the new Galaxy S4 as a potential iPhone challenger in terms of hype and mindshare, but mobile ad firm Velti offers a different perspective in its February summary of global exchange data from its network. The company still sees iOS and iPhone dominating among mobile advertisers, despite the rising tide of Android devices.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/babHigJSs_E/

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Wednesday, March 13, 2013

Two Studies Find Promising News Ways To Detect Alzheimer?s Earlier

Sleep patterns and markers in spinal fluid may hint at the first signs of the neurodegenerative disorder.

The Centers for Disease Control estimates that 5 million Americans have Alzheimer?s disease, and while there are no effective treatments, experts believe that detecting the disease early can help patients to strengthen memory and cognitive functions and potentially slow down the buildup of brain plaques that are the hallmark of the condition. Two studies, both published in the?Journal of the American Medical Association?(JAMA), hint at potentially encouraging ways to identify those who might be at risk, at the earliest possible stages of disease.

(MORE: Study Shows Alzheimer?s Protein May Not Spread like a Virus)

In one study from the Washington University School of Medicine in St. Louis, ?researchers found that levels of the protein amyloid, which makes up these plaques, were correlated with poor sleep quality. Previous studies in animals showed that animals that slept less tended to develop more plaques, but it wasn?t clear whether poor sleep can contribute to the formation of amyloid plaques, or whether the build up of these deposits causes disturbances in sleep.

To study the connection further, the scientists asked 145 cognitively normal individuals aged 45 to 75 who were enrolled at the Alzheimer?s disease research center to keep a diary of their sleep patterns for two weeks. The volunteers recorded when they went to bed, when the woke up in the morning, how many naps they took and whether they felt sleepy during the day. The scientists had the advantage of already having samples of the participants? spinal fluid, so they could also match up the sleep records with the level of amyloid protein in the brain of in each patient.

All of the participants slept about the same amount, but there were stark differences in the quality of that sleep. Thirty two participants showed higher levels of amyloid build-up that was classified as pre-clinical Alzheimer?s disease, and also had worse sleep quality. These volunteers were less likely to spend time their time in bed in restful, deep sleep than those with lower levels of amyloid.

MORE: New Research on Understanding Alzheimer?s

Because none of the participants were experiencing any symptoms of Alzheimer?s, the researchers believe that such sleep disturbances may be among the earliest signs of the disease, and could help to identify those at risk of developing Alzheimer?s. It?s still possible that the link between poor sleep and?Alzheimer?s?disease works both ways, and that amyloid build-up could interfere with neurological sleep functions while at the same time restless sleep could also create conditions that promote the deposit of the amyloid protein.

Either way, the scientists believe that sleep disturbances could not only help to identify the most vulnerable populations but also help in testing of new treatments. Measuring the effect that novel drugs or therapies have in improving sleep quality and lowering amyloid levels could serve as a marker for their effectiveness. ?Sleep measures themselves could be used as markers of brain function, thereby?facilitating faster and easier clinical trials of promising?treatments in the preclinical and early clinical stages of Alzheimer?s Disease,? the authors write.

(MORE: Is Alzheimer?s Caused by Contagious Proteins?)

In the second study, researchers from the University of Minnesota focused more specifically on which markers of amyloid were the best representatives of the protein?s buildup in the brain. They studied spinal fluid from 107 adults, about half of whom showed signs of Alzheimer?s or cognitive impairment, and half of whom did not. They then compared their results to those of 10 younger and?cognitively?normal controls to ensure that they were zeroing in on the most reliable markers for Alzheimer?s.

MORE: Use it or Lose it: Keeping Brain Active May Help Ward Off Alzheimer?s

For years now, scientists have known that the amyloid protein that builds up in the neurodegenerative condition actually comes from a larger protein that is broken down into various fragments. So the Minnesota researchers concentrated on two of these, the beta-amyloid trimers and beta-amyloid*56. They found that levels of these fragments were elevated among the participants who already showed symptoms of Alzheimer?s, but were lower among those who didn?t have the symptoms and among the younger controls. Levels of these compounds also increased with age, suggesting that they serve as a viable target for new treatments as well, since eliminating or hampering their aggregation might hold off some of the symptoms of Alzheimer?s.

MORE: Scientists Identify Rare Gene Mutation that Protects Against Alzheimer?s

Both methods require additional confirmation, but as experts learn more about the processes that drive Alzheimer?s, they hope to find more interventions that can reduce the severity of the disease or, ultimately prevent it altogether.

Source: http://news.yahoo.com/two-studies-promising-news-ways-detect-alzheimer-earlier-153031285.html

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Friday, March 1, 2013

US boosts aid to Syrian opposition, rebel fighters

U.S. Secretary of State John Kerry, left, talks to Syrian opposition coalition leader Mouaz al-Khatib, during an international conference on Syria at Villa Madama, Rome, Thursday, Feb. 28, 2013. The United States is looking for more tangible ways to support Syria's rebels and bolster a fledgling political movement that is struggling to deliver basic services after nearly two years of civil war, Kerry said Wednesday. (AP Photo/Riccardo De Luca)

U.S. Secretary of State John Kerry, left, talks to Syrian opposition coalition leader Mouaz al-Khatib, during an international conference on Syria at Villa Madama, Rome, Thursday, Feb. 28, 2013. The United States is looking for more tangible ways to support Syria's rebels and bolster a fledgling political movement that is struggling to deliver basic services after nearly two years of civil war, Kerry said Wednesday. (AP Photo/Riccardo De Luca)

U.S. Secretary of State John Kerry, center, sits between Italian Foreign Minister Giulio Terzi, right, and British Foreign Secretary William Hague during meetings at Villa Madama in Rome on Thursday, Feb. 28, 2013. Rome is the fourth leg of Kerry's first official overseas trip, a hectic nine-day dash through Europe and the Middle East. (AP Photo/Jacquelyn Martin, Pool)

Syrian National Coalition President Mouaz al-Khatib, second from left, arrives for meetings at Villa Madama in Rome on Thursday, Feb. 28, 2013. (AP Photo/Jacquelyn Martin, Pool)

(AP) ? The Obama administration said Thursday that it will provide the Syrian opposition with an additional $60 million in assistance and ? in a significant policy shift ? will for the first time provide nonlethal aid like food and medical supplies directly to rebels battling to oust President Bashar Assad.

The move was announced by U.S. Secretary of State John Kerry at an international conference on Syria in Rome, and several European nations are expected in the coming days to take similar steps in working with the military wing of the opposition in order to ramp up pressure on Assad to step down and pave the way for a democratic transition.

"We do this because we need to stand on the side of those in this fight who want to see Syria rise again and see democracy and human rights," Kerry said. "The stakes are really high, and we can't risk letting this country in the heart of the Middle East being destroyed by vicious autocrats or hijacked by the extremists."

"No nation, no people should live in fear of their so-called leaders," he said, adding that President Barack Obama's "decision to take further steps now is the result of the brutality of superior armed force propped up by foreign fighters from Iran and Hezbollah."

Kerry and senior officials from 11 countries most active in calling for Assad to leave said in a joint statement released by the Italian foreign ministry that they had agreed in Rome on "the need to change the balance of power on the ground." It said the countries represented "will coordinate their efforts closely so as to best empower the Syrian people and support the Supreme Military Command of the Free Syrian Army in its efforts to help them exercise self-defense."

Britain and France, two countries that Kerry visited before Italy on his first official trip as secretary of state, have signaled that they want to begin supplying the rebels with defensive military equipment such as combat body armor, armored vehicles, night vision goggles and training. They are expected to make decisions on those items in the near future in line with new guidance from the European Union, which still bars the provision of weapons and ammunition to anyone in Syria.

"We must go above and beyond the efforts we are making now," said Italian Foreign Minister Giulio Terzi, who hosted the conference. "We can no longer allow this massacre to continue."

Appearing beside Terzi and Kerry, the leader of the Syrian opposition coalition, Mouaz al-Khatib, delivered a forceful and emotional demand for Assad to stop the brutality of his forces that have in recent days launched scud missile attacks on the city of Aleppo that have been roundly condemned by much of the Western and Arab worlds

"Bashar Assad, for once in your life, behave as a human being," Khatib said. "Bashar Assad, you have to make at least one wise decision in your life for the future of your country."

The opposition has been appealing for some time for the international community to boost its support and to provide its military wing with lethal assistance, and while al-Khatib did not mention those requests, he pointedly made no reference to the new assistance that Kerry announced. Instead, he urged outside nations to support the creation of protected humanitarian corridors inside Syria, which the foreign ministers said they had "positively considered" by made no decisions.

Kerry defended the limited U.S. assistance, saying it was just part of what was being offered and that other countries would fill in any gaps. He said he was confident that the "totality" of the aid should be enough to prod Assad to start changing his calculations on remaining in power.

"We're doing this, but other countries are doing other things," he replied, without going into specifics. "I am confident the totality of this effort is going to have an impact on the ability of the Syrian opposition to accomplish its goals." Kerry said Thursday's meeting in Rome marked the "beginning of a process that will in fact change his (Assad's) calculation."

Washington has already provided $385 million in humanitarian aid to Syria's war-weary population and $54 million in communications equipment, medical supplies and other nonlethal assistance to Syria's political opposition. The U.S. also has screened rebel groups for Turkey and American allies in the Arab world that have armed rebel fighters.

But until now, no U.S. dollars or provisions have gone directly to rebel fighters, reflecting concerns about forces that have allied themselves with more radical Islamic elements since Assad's initial crackdown on peaceful protesters in March 2011.

The $60 million in new aid to the political opposition is intended to help the opposition govern newly liberated areas of Syria by aiding in the delivery of services and improving rule of law and human rights as well as to blunt the influence of extremists who have made inroads in some places.

The rations and medical supplies for the fighters will be delivered to the military council for distribution only to carefully vetted members of the Free Syrian Army, U.S. officials said.

The U.S. will be sending technical advisers to the Syrian National Coalition offices in Cairo to oversee and help them spend the money for good governance and rule of law. The advisers will be from non-governmental organizations and other groups that do this kind of work.

The foreign ministers' presentation was disrupted by one protester who called on them to "stop supporting terrorists."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-02-28-US-Syria/id-6244239c6e1445edbb6ef126e7d3c98b

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